Home Asia Featured News Indian trials on multiple Covid-19 drugs make progress, have Atmanirbhar Bharat tilt

Indian trials on multiple Covid-19 drugs make progress, have Atmanirbhar Bharat tilt

As per the CuRED portal, two other testing kits for Covid-19 that have been developed by CSIR laboratories are currently under evaluation by the Indian Council of Medical Research




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India, Oct. 21 — At least two existing medicines that were repurposed for the of disease (Covid-19) have entered into phase III clinical trials that are being conducted by the Council for Scientific and Industrial Research (CSIR). This includes the antiviral medicine Umifenovir and a medicine that is used to treat blood infection caused by resistant gram-negative bacteria MW Sepsivac.

CSIR has also been working with phytopharmaceuticals – or herbal medicines – including an antiviral AQCH, which is about to enter phase III trial.

“We started a big clinical trial on MW Sepsivac as an immunomodulator and this trial has gone well. Phase II data has come out and now we are planning to launch the phase III trial. This immunomodulator will become a great for Covid-19 patients. We are also working with phytopharmaceutical with AYUSH ministry. Today, our data for AQCH has come. This will be the first phytopharmaceutical to be evaluated with the modern trial approach,” said Dr S Chandrashekhar, director, Indian Institute of Chemical (IICT) that is coordinating the trials.

It is also working on several combination therapies using antiviral drugs along with anti-gout medicine colchicine and a drug used to treat chest congestion called bromhexine. Approvals for phase I trial for these combination therapies have been received by the institute.

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Dr Chandrashekhar was speaking on the occasion of the union and minister Harsh Vardhan launching the web portal for CSIR Ushered Repurposed Drugs (CuRED) that will provide updated information about drug trials and diagnostics being developed by CSIR laboratories.

“CSIR had started several trials for repurposed drugs to fight Covid-19 in with several companies. This portal will have information on these trials,” said Dr Shekhar Mande, DG, CSIR.

Also Read: 30 million frontline workers to get in phase 1

Apart from trials of repurposed drugs, IICT is also working on developing processes for at least 15 pharmaceutical compounds that are currently in trial across the world as possible therapy for Covid-19 but aren’t manufactured in India.

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“Keeping the aim of Atmanirbhar Bharat in mind, we are also working on corticosteroids that are given to moderate and severe Covid-19 patients. However, we import 90% of these corticosteroids from China. Now multiple CSIR institutes are working not only to make these corticosteroids but another 15 API (active pharmaceutical ingredients) which are currently undergoing clinical trials for the of Covid-19 across the world. We are sure in the next two to three months, we will be able to develop processes for 10 drugs and go to industrial partners for scale up and do clinical trials to show of Indian generics,” said Dr Chandrashekhar.

Also Read: What is ‘human challenge’ that cleared to speed up trial?

As per the CuRED portal, two other kits for Covid-19 that have been developed by CSIR laboratories are currently under evaluation by the Indian Council of Medical Research (ICMR). One test named Feluda, which uses paper strip test developed by scientists from Institute of Genomics and Integrative Biology, has already been approved and is likely to hit the markets soon. The test barcodes the Cas9 protein – a component of the CRISPR gene editing system – to interact specifically with the genetic material of SARS-CoV-2 that causes Covid-19.

“So far, over 100 big or small technologies have been developed around Covid-19 by CSIR in the last nine months and most have been transferred to the industry. Finding a new molecule that specifically works against Covid-19 will take time, but in the meantime, scientists have been working with existing drugs to see whether some can be effective against Covid-19 such as Favipiravir that was used for in Japan or drugs that were used for Ebola. There are at least 25 drugs in various phases of trial and some have been successful. CSIR has also fulfilled my long-cherished dream that Ayurveda drugs be subjected to modern scientific scrutiny. All has happened in just nine months,” said union minister Harsh Vardhan.

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